Mechanisms of spinal cord compression and their consequences in the epidural space

The pathophysiological processes following spinal cord trauma are being investigated. The two main pathologies studied are herniated disc and atlanto-axial instability. Special emphasis is placed on the inflammatory processes triggered in the epidural space (=spinal canal). Inflammation parameters (inflammation mediators and cytokine profiles) in the intervertebral disc material and in the cerebrospinal fluid are investigated, as well as their influence on pressure and blood flow within the spinal cord. Since the herniated disc in dogs is recognized as a clinical model for spinal cord trauma in humans, the results may also be of importance for human medicine. Thanks to the results obtained, the treatment of the above-mentioned pathologies should be better understood and, as a consequence, optimized.

Biomechanics of the spine and spinal implants

Studies evaluate the safety and biomechanical properties of different implants used to stabilize the spine in dogs. The main focus is on cervical spondylomyelopathy (CSM, Wobbler Syndrome) and atlanto-axial instability. small animal surgery staff are developing new implants to stabilize the spine in collaboration with partners from the medical industry. Clinical studies investigate, among other things, the long-term changes following spinal stabilization.