Leptospirosis is a bacterial infection of our domestic dogs that can be transmitted from animals to humans and can lead to acute kidney failure, lung bleeding, liver involvement and coagulation problems. The topics of the individual projects range from the epidemiology of the disease in dogs, to the cellular level with cytokine expression profiles and biomarkers of endothelial dysfunction, to clinical issues such as disorders of hemostasis and heparin-free extracorporeal blood purification procedures and plasmapheresis
Acute kidney failure is a sudden, life-threatening disease in which the kidneys lose their excretory function within hours and days. A better understanding of the resulting blood poisoning (uremia) is an important prerequisite for the sensible use of therapeutic measures such as diet and medication. We are investigating the influence of diet and the inflammatory events in the progression of chronic kidney disease.